When you take Ozempic, it activates GLP-1 receptors in your body, causing an increase in insulin. Celebrities seeking to lose weight is just one factor driving a worldwide shortage of Ozempic, a drug originally approved to treat Type 2 diabetes that can also result in significant weight loss. Nausea usually lessens as you continue to. Press and hold in the dose button until the dose counter shows 0. 5mL and 4mg/3mL are currently out of stock due to a global shortage. The maximum recommended dosage is 2 mg once weekly. Become an Oprah Daily Insider now to access this conversation and the. These adverse reactions occurred more commonly on OZEMPIC than on placebo and occurred in at least 5% of patients treated with OZEMPIC. Helps your pancreas produce more insulin when your blood sugar is high. Sept. Of note, Ozempic is now approved in a higher 2 mg dose, and effectiveness compared to Mounjaro with this higher dose may vary. Google searches in the US for the viral drug ‘Ozempic’ have skyrocketed by 436% in the past five years, as well as searches for the side effect ‘Ozempic face’ have exploded by 67% in the. Store at 2 to 8 degrees Celsius. In pregnant animals, Ozempic was linked to pregnancy loss and birth defects. To people using Ozempic for weight loss: Do what you have to do. Ozempic is an injectable medication that is FDA approved to treat Type 2 diabetes. D. While many pharmacists across the U. In clinical trials, constipation was one of the most commonly reported side effects among people taking the medication. Constipation. These medications can help people with type 2 diabetes, overweight, and/or obesity become healthier by reducing their risk of heart disease, stroke and diabetes, and certain types of cancer. Photo: TNS While hosting Oprah Daily’s The Life You Want Class: The State of Weight. 25 mg once weekly for four weeks to thirty days. In many cases, patients have said these drugs are succeeding where all other diets, exercise, and. Ozempic is indicated for the treatment of adults with insufficiently controlled. GLP-1 receptor agonists are associated with gastrointestinal side effects. Greasy foods[23] are already digested slowly. It. The Ozempic Pen may stop working sometimes due to some errors. Ozempic Goes Way Off-Label. Side Effects. The most commonly reported side effects of Ozempic involve the gut. 5 mg dose, 2 mg/3 mL (subcutaneous solution, 1 pen) as soon as it is available for selection in the EHR, starting in March. One of the most enduring ways to save money on long-term, high-priced medications like Ozempic is to purchase health insurance. Key takeaways: Ozempic (semaglutide) is an injectable medication that treats Type 2 diabetes in adults. That helps treat type 2 diabetes, Dr. 5 mg once weekly for four weeks. It helps to lower your blood sugar levels and A1C. Ozempic for PCOS. Ozempic is a liquid medication that comes as a pen you use to self-inject in your skin once a week at any time of day. If they are consumed while taking Ozempic, gastrointestinal side effects are more common. Cuts are still far off. Ozempic is given as an injection under your skin. Case reports of acute kidney injury in patients taking the glucagon-like peptide 1 (GLP-1) receptor agonists exenatide and liraglutide have been reported. ) Alcohol could also increase your risk of low blood sugar. This means alcohol could make Ozempic not work as well as usual. 25 dose, for a month. Bhuyan. are turning to Canadian pharmacies to buy the drugs for cheap. once per week, any time of day. $9 at Amazon. 25 dose, for a month. ; She told the outlet she started using it last December, and lost 42 pounds. To date, however, the makers of Ozempic and. Nov. What is semaglutide? Semaglutide (Rybelsus and Ozempic) is used with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus (not for type 1 diabetes). If your Medicare co-pay is higher than $916. Started on 0. Rybelsus is an oral medication. Telehealth and social media are playing a significant role in driving demand for Ozempic, a prescription drug that treats Type 2 diabetes, experts told CNN. Placebo (N=262) % OZEMPIC 0. What is Ozempic®? Ozempic® (semaglutide) injection 0. A new report finds 2 out of 3 people on GLP-1 drugs like Ozempic stop within a year. Her son, 17, has lost 65 pounds on Ozempic, and her 21-year-old daughter has lost 50 on it. 5 mg would be available before the end of 2023 and there. Ozempic is a once-weekly injection; Saxenda is a daily injection. Doctors also typically start patients at the lowest dose and then ramp up the dosage every four weeks or so, explains Kunal Shah, MD, an assistant professor in the division of endocrinology at the. We’re seeing young people come in looking very aged,” she said. After that, your dose may be increased every 4 weeks up to 2 mg once weekly, depending on how you respond to the medication. medicine. 99 per month, plus your standard copay for each visit. Taking Ozempic for weight loss, which is considered an off-label use, isn’t covered under Medicare Part D. Vomiting. 25 milligrams to . Clinical Review Report: Semaglutide (Ozempic): (Novo Nordisk Canada Inc. Ways to Save on Ozempic. The Talk UK host, 71, spoke to the Daily Mail and revealed that she now weighs under 100 lbs. Gastrointestinal side effects. 1. Increased global demand for semaglutide products is impacting availability of Ozempic (semaglutide) in Australia. Ozempic works by producing a synthetic version of the hormone GLP-1. Ozempic®, along with diet and exercise, is proven to improve blood sugar in adults with type 2 diabetes. 0. 9 kg (13 lb) for semaglutide (Ozempic). The 2 mg dose was approved by the FDA in March 2022. Ozempic prefilled single-patient-use pens are available in three strengths: 2 milligrams (mg) per 1. The FDA Warned Ozempic Users. In rare cases, Ozempic side effects may not go away. 5 mg or 1 mg is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus and to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction or nonfatal stroke) in adults with type 2 diabetes. Ozempic (semaglutide) +. Jaap Arriens/NurPhoto/Getty Images. It also aids weight loss, and is sold as Wegovy to treat obesity. 25 mg, given for 4 weeks. Nausea, vomiting, and abdominal pain are common with Ozempic. on Ozempic® By adding once-weekly Ozempic® to your type 2 diabetes management plan, you and your health care provider have taken an important step in helping you lower your blood sugar. Eligibility and other restrictions apply. Fresh fruits that are considered diabetes-friendly due to sugar content, which includes apples, berries, peaches, pears and more. Note: Trulicity is a biologic medication that is not available in a. You may have digestive issues. CNN —. I have lost 13 pounds, plus three inches off my waistline, and I’ve gained a sense of body confidence that I haven’t had. Semaglutide, the active ingredient in Ozempic and Wegovy, can be a powerful tool for promoting weight. The chemistry explains how Ozempic works and what its main side effects are. It was approved in 2017 but only became a social media weight loss sensation in 2022, as Diabetes Daily notes. 2 mg/3 mL, used for starting and maintenance dosages. The side effects associated with the use of this drug include nausea, diarrhea, abdominal pain, constipation, headache, says Dr. Sep 22, 2023. If you’re taking Ozempic, you should aim to include fruits, vegetables, whole grains, healthy fats, and protein-rich foods in your diet. The change in menstrual cycles may be associated with mood disturbances that can have an effect on. More patients on Ozempic 0. Your Hunger Comes Back. 99 per month, plus $129 for the first visit, followed by $99 each month thereafter. Often, the pen stops working when its needle is blocked. -- is approved by the U. Questions about Ozempic®? • Textª BEGIN to 21848 to sign up for a free text-based savings and support program • Talk to a Diabetes Health Coach bySemaglutide is a glucagon-like peptide-1 receptor agonist. Tell your health care provider right away if you get symptoms which may include: pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay-colored stools. The list includes stringy raw fruits and vegetables, such as pineapple or celery, and those with a tough peel, such as an apple. Rybelsus is an oral version of semaglutide — the active ingredient in Ozempic. It’s usually prescribed at . Some people on the drug say they’ve developed “Ozempic face,” which is a gaunt look. Book an appointment. 4 kg (25 lb), on average, compared to 5. ’. If you overdose on Ozempic, you’ll likely experience more intense side effects like nausea, vomiting, and diarrhea. It also helps to reduce the amount of sugar released by your liver and slows. *. Taken once a week by injection in the thigh, stomach or arm, Ozempic comes with common side effects like nausea and diarrhea, and sometimes vomiting or constipation, Ania Jastreboff, M. Ozempic (semaglutide) is a subcutaneous injection used in people with type 2 diabetes. Warning. But while Ozempic is designed to treat type 2. Studies on Ozempic have proven users lose weight for several years. Not only are many health insurance plans cheaper than a year’s expenditure on Ozempic, but some plans are also surprisingly affordable. They both can cause nausea, vomiting, and diarrhea. Information on the product label and product monograph indicates the Health Canada. Rybelsus and Ozempic have many similarities but also have significant differences. Earlier this month, the FDA approved the drug Zepbound to treat obesity. Ozempic belongs to a new class of medications called. Low blood sugar, or hypoglycemia, is more likely with this interaction. If you’re new to fiber supplements, it’s best to start with a small amount, like ½ teaspoon in an 8-ounce glass of water once a day, according. Check the Ozempic® flow with each new pen. More than 750 people in 20 states developed severe fungal infections as a result, and 64 people died from the injections. See also Warning section. 5 on month 2, then 1. Key takeaways: Ozempic (semaglutide) is an injectable medication that treats Type 2 diabetes in adults. Double-check that all necessary information is included. 25 mg, 0. The soaked ginger may be squeezed to get the extract out of it. Here are five tips to keep in mind when labeling your medication for travel: Make sure the label is visible and easy to read. Ozempic is an injectable medication that’s used to balance blood sugar levels in people with Type 2 diabetes. In conclusion: Headache is a common symptom. Nausea. GLP-1 agonists, like Ozempic or Wegovy, reduce cravings and slow gastric emptying. But, research on Ozempic for prediabetes is lacking. Rybelsus (semaglutide) and Ozempic (semaglutide) are brand-name drugs. 1 interaction. Pull off both needle caps. One of the side effects of type 2 diabetes drugs like Ozempic and Mounjaro is increased satiety, or a feeling of fullness after meals—something that can make indulging in vacation treats challenging. Diarrhea. Katja Ogrin/Getty Images. Side Effects. The exact cause of headaches with Ozempic is not fully understood, but it is believed to be related to changes in blood sugar levels. Ozempic is on the rise. Wegovy is sold at higher doses than Ozempic. Wegovy is associated with several common side. 5. Though every person is different, experts have noticed. com. Connecticut’s state employee health plan was on course to spend $30 million this year on a class of diabetes drugs that is exploding in popularity for weight loss. The manufacturer. It's marketed in Canada by Novo Nordisk. The maximum recommended dosage is 2 mg once weekly. If you are having to pay the full price, you may be able to save money on Ozempic by using an online discount coupon or you may be eligible for patient financial assistance through Novo Nordisk. With. The chemistry explains how Ozempic works and what its main side effects are. As prices rise, semaglutide users are turning to online. Type 2 diabetes is a common medical condition where you have too much sugar in your blood. It’s become the worst-kept celebrity weight loss secret of the moment with people like Elon Musk tweeting about taking Wegovy and Andy Cohen commenting on Ozempic’s widespread use. Another common side effect is. 7. A doctor may recommend. Often, the pen stops working when its needle is blocked. It is often associated with weight loss, malnutrition, or chronic illness. Ozempic is a brand name for semaglutide. It may cause mild side effects, like stomach pain, or more serious side effects, such as diabetic retinopathy. Also, though it is not mentioned on Ozempic's website, doctors have reported some patients, their appetites so suppressed, experience malnutrition. Reflux. The most common side effects of these drugs are gastrointestinal and include nausea, vomiting, bloating and fullness, Cash said, but other side effects have been reported, including potential long. Ozempic side effects may also cause rashes and itching on your face. Females had severe headaches, backache, nausea, and vomiting during the perimenstrual period while they were on Ozempic (or Wegovy). Ozempic ( semaglutide) is a brand-name prescription medication for people with type 2 diabetes to use alongside healthy eating and exercise to improve blood sugar levels. Helps prevent your liver from making and releasing too much sugar. S. Uses. 7 kg (17 lb) to 11. Avoiding foods high in fat, refined carbohydrates, and foods with added sugar may also help. [11] [12] [13] The most common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation. Drugs like Ozempic and Wegovy help with weight loss but price can be an obstacle : Shots - Health News The new weight-loss drugs can be life-changing for people facing health conditions worsened. Ozempic side effects commonly include nausea and diarrhea. The first indication is to improve glycemic control in adults with Type 2 diabetes (in conjunction with diet and exercise). Tear off the paper tab. OZEMPIC is available as a liquid that comes in a prefilled pen. 4 mg once weekly) for chronic weight management in adults with obesity or overweight with at least. David J. Ozempic ® (semaglutide) injection 0. [11] [14] [15] [16] In 2020, semaglutide was the 129th most commonly prescribed medication in the United States, with more than 4 million prescriptions. It's also part of the reason why these. Despite its popularity, heath experts warn against. 2 mg/3 mL, used for starting and maintenance dosages. 3 percent. Hair loss. Ozempic can interact with insulin. About 3% to 5% of people in clinical studies experienced constipation while taking Ozempic. 5) You’re not getting enough sleep. Rybelsus is an oral version of semaglutide — the active ingredient in Ozempic. In order to get the most effective results, on Ozempic as well as Wegovy, becoming active is a must — and Dr. To find out about Ozempic’s interactions, see this article. There are other medications in. More On: sharon osbourne. Gastrointestinal upset (upset stomach) Nausea. Price: from $19 for an appointment plus the cost of Ozempic. Maher told me she hopes to stay on the. Dosage. The diabetes medication has taken off as a weight loss drug and during a recent interview with Piers. What is a “Gaunt Face”? A gaunt look refers to a thin, emaciated, or haggard appearance, often characterized by sunken cheeks, visible bones, and/or wrinkles. If you’re planning to become pregnant, you should plan to stop taking Ozempic at least 2 months before pregnancy. Getting started. after using Ozempic, an FDA-approved prescription medication for people with type 2 diabetes. Ozempic Foods: What to Eat and Avoid While on Semaglutide, According to Doctors 6 Foods to Avoid While on Ozempic to Help Manage Side Effects Plus, what. Semaglutide lowers blood sugar and was originally approved by the Food and Drug Administration (FDA) to treat type 2 diabetes. The potential to make life boring and miserable may be an unwelcome side effect of drugs like Ozempic and Wegovy. 1 pounds over the course of 40 weeks on Ozempic. Osbourne, 71. Continue reading to learn about. In most cases, you should not take Ozempic if you’re pregnant. When combined with your insurance coverage, the Ozempic savings card or the diabetes savings card may bring your Ozempic cost down to as low as $25 per month for up to 24 months. 1. The semaglutide drug has become popular for weight loss but has a variety of warnings about gastrointestinal distress. Valocchi lost weight at this pace, but other factors cancontribute to Ozempic face, per Salas-Whalen. Tell your health care provider right away if you get symptoms which may include: pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay. Ozempic ® is a prescription medication. Celebrities seeking to lose weight is just one factor driving a worldwide shortage of Ozempic, a drug originally approved to. People may experience nausea, vomiting, or diarrhea when they begin taking Ozempic. 02, you can save money by using a GoodRx coupon instead. These side effects occurred at rates higher than the placebo-treated groups (receiving an inactive treatment). Treatment options for headaches with Ozempic may include adjusting your. Ozempic is in a class of drugs known as glucagon-like peptide-1 (GLP-1) agonists (incretin mimetics). Generally, a person can expect to lose 15 percent of their body weight, explains Dr. Patent use: A METHOD OF TREATING TYPE 2 DIABETES COMPRISING ADMINISTERING SEMAGLUTIDE ONCE WEEKLY IN A AMOUNT OF 1. “Ozempic face” is a term for common side effects of the type 2 diabetes medication semaglutide (Ozempic). When taken with warm water, it also increases bowel movements and relieves constipation. Ozempic (semaglutide) is a prescription injectable pen used along with a healthy diet and exercise to treat type 2 diabetes. Most women observed an increased flow and duration of menstrual cycles. The popularity of Ozempic, Wegovy, and other GLP-1 drugs has skyrocketed recently due to their ability to help people lose weight. Yes. Ozempic ® (semaglutide) injection 0. Simply put, Ozempic improves blood sugar levels by helping the pancreas release insulin and limiting the release of sugar into the bloodstream. Lemon relieves nausea through its pleasant scent. OZEMPIC ® semaglutide) njection, or ubcutaneous se 2 FULL PRESCRIBING INFORMATION WARNING: RISK OF THYROID C−CELL TUMORS • In rodents, semaglutide causes dose-dependent and treatment-duration-It also helps to slow down the emptying of your stomach, which means you'll feel fuller for longer after a meal. I started taking the drug before its wonder-weight-loss properties hit the news, before Jimmy Kimmel made an Ozempic joke minutes into hosting the Oscars, before thin women who wanted to be thinner began. #ozempic #ozempicinjection #diabetes Learn how to use an OZEMPIC Injection pen the right way. Since this medication may be capable of promoting weight reduction and improving insulin sensitivity, it might help curb the. Now she prefers the kale salad. How Long Do Side Effects Last? Mild, common side effects typically go away after a few days, though some may last a few weeks. S. But medications are usually needed to help keep your blood sugar levels under control. People say the popular weight-loss drug semaglutide makes it hard to stomach their favorite foods. 5 mg or 1 mg is an injectable prescription medicine used: on Ozempic® By adding once-weekly Ozempic® to your type 2 diabetes management plan, you and your health care provider have taken an important step in helping you lower your blood sugar. That buzz is causing a shortage, which can have serious consequences for people with Type 2 diabetes. See Table 7. 85 for brand-name drugs or 15% of your coinsurance or copay—whichever is less. HbA1c was 79, sugar cravings and blood sugar out of control. FDA Adds New Side Effect Warning to Ozempic Label. "You can lose so much weight and. Shelf lifetime is 36 Months. Gastrointestinal side effects. semaglutide + canagliflozin. 0 MG TO A SUBJECT IN NEED THEREOF. 25 for six weeks and . Psyllium Husk Powder. Although not FDA-approved for weight loss, Ozempic may help people with type 2 diabetes lose weight. Instead of injecting Ozempic once weekly, Rybelsus is a pill that you take by mouth every day. Constipation. Rarely, Ozempic can cause more serious side effects, including inflammation of the pancreas, changes in vision, and serious allergic reactions. Ozempic, and semaglutides in general, have been proven to help people lose weight . However, some insurance companies and employers are halting. 3. Based on that number, AARP said Ozempic was the 10th costliest drug covered by Medicare Part D. That could be a problem for. Ozempic prefilled single-patient-use pens are available in three strengths: 2 milligrams (mg) per 1. . Patients in the U. 7 billion from thematic ETFs so far this year, compared with $2. NCBI Bookshelf. More On: ozempic. Went up to 0. Kirkland & Ellis LLP. It is injected once weekly under the skin (subcutaneously) of the abdomen, thigh or upper arm. How Ozempic ® works to lower blood sugar and A1C in adults with type 2 diabetes. Taking Ozempic for weight loss, which is considered an off-label use, isn’t covered under Medicare Part D. In people with type 2 diabetes, treatment with Ozempic can lower. It also helps to reduce the amount of sugar released by your liver and slows down. In adults with type 2 diabetes and known heart disease, Ozempic® reduces the risk of major cardiovascular events such as stroke, heart attack, or death. It. In. Buy a health insurance policy. But it is a diabetes medicine. I couldn’t keep it up. Rao. Insurance. The term "Ozempic face" has been coined and used on social media to describe what some people say is an aged or gaunt look on the faces of people who use the medication. 0 MG TO A SUBJECT IN NEED THEREOF. I’ve been on Ozempic for about a year and a half for my type 2 diabetes. The current drug shortage has limited. It’s an injectable medication that’s designed to help with blood sugar management for people with type 2 diabetes. This injection is one you only take once a week, and so yes. 5 milligrams. Although medication can help some individuals lose weight, obesity is not a simple disease of inactivity or overeating. 2. Quite bad stomach cramps and nausea for the first month. That said, because the drug regulates blood sugar and appetite, Ozempic can cause rapid weight loss which may contribute to a saggier and/or flatter tush, says Dr. It also reduces the amount of sugar released into the blood and slows down your digestion. You’re stressed. Although steady state levels are reached in 4 to 5 weeks, clinical effectiveness with Ozempic will vary from person to person and may take longer due to unique factors such as age, weight, amount of body fluid, additional medications you take, kidney or liver function, or your other medical conditions. Maximum savings of $150 for a 1-month prescription, $300 for a 2-month prescription, and $450 for a 3-month prescription. But after a year on the medication. Stomach pain. Ozempic and Saxenda have some of the same side effects. 5 mg, given after 4 weeks of the starting dose. Ozempic (semaglutide) is an injectable medication used to help control blood glucose (sugar) levels in adults with Type 2 diabetes. after using Ozempic, an FDA-approved prescription medication for people with type 2 diabetes. Matas has been on Ozempic for a year and seven months. Side Effects. 3. An Ozempic diet is one that also helps prevent high blood sugar. But the relationship between Ozempic and pancreatitis isn’t so. A doctor may recommend. Ozempic, a medication used to treat type 2 diabetes, is being used off-label as a weight-loss drug. Both Ozempic and Trulicity have two indications. Gradual dose escalation designed to help patients adjust to therapy 1,a. Northern Mariana Islands. Ozempic, known generically as semaglutide, was approved in 2017 by the U. Mounjaro led to weight loss of 7. Does Ozempic make you tired? In short: maybe. Ozempic is a type 2 diabetes drug used to manage blood sugar. Colbert. Popular semaglutide injectable Ozempic will now have a warning about intestinal blockage after the Food and Drug Administration accepted manufacturer Novo Nordisk's proposed changes to the drug's. Diarrhea. To treat her own sagging skin, Mechoullam started using filler for her chin and cheeks. Sesame is easy and convenient. It can cause sagging and aging of facial skin. DIABETES-FRIENDLY MEAL PLANNING What you eat is essential in a type 2 diabetes diet, but how much you eat is just as important. 1 recommended dosageIt is important to begin ePrescribing Ozempic ® (semaglutide) injection - Ozempic ®, 0. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. Plus, plus, under your own. The. There is a worldwide shortage of this diabetes medicine. It also aids weight loss, and is sold as Wegovy to treat obesity. If a dose is missed, administer OZEMPIC as soon as possible within 5 days after the missed dose. But because of how it works, some people taking Ozempic lose weight. Worley works to ensure his patients embrace this as a new lifelong habit, even if. And it’s pretty common. Ozempic can tamp down on feelings of hunger and, once you stop taking it, those sensations return. Ozempic is a GLP-1 agonist medication used for treating high blood sugar in people with type 2 diabetes. Nov. The medication could alter the way food. By Dani Blum and Callie Holtermann. Questions about Ozempic®? • Textª BEGIN to 21848 to sign up for a free text-based savings and support program • Talk to a Diabetes Health Coach by Semaglutide is a glucagon-like peptide-1 receptor agonist. Bloating. Ozempic is a glucagon-like peptide-1 receptor agonist (GLP-1RA) that slows down stomach emptying. TGA alerts relate to the shortage in Australia. The report, released Wednesday by data-analytics firm Trilliant Health, shows that quarterly prescriptions quadrupled between early 2020 and the end of last year. It may also result in weight loss. When you take Ozempic, it activates GLP-1 receptors in your body, causing an increase in insulin. “As soon as he. supplies should be conserved for patients who are stabilised on Ozempic who have no other treatment options; it is not known when the medicine will be available in sufficient quantities to meet the ongoing high demand. Doctors said the practice is not advisable, especially for those on Ozempic. Also, though it is not mentioned on Ozempic's website, doctors have reported some patients, their appetites so suppressed, experience malnutrition. "I started on Ozempic last December and I've been off it for a while now, but my warning is don't give it to teenagers, it's just too easy," the 71-year-old said. Meanwhile, other medics are sounding the alarm about additional side effects, including blurred vision, kidney failure and gallstones. Please click here for Prescribing Information and Medication Guide for Ozempic®. If additional blood sugar control is needed, increase to 2mg every week. By CT Jones. The US Food and Drug Administration has updated the label of the diabetes drug Ozempic to acknowledge reports of blocked intestines in some people using the. If you qualify in 2022, you could pay just $8. Produced by Nina Feldman and Alex Stern. Common side effects may include: low blood sugar (in people with type 2 diabetes); upset stomach, heartburn, burping, gas, bloating; nausea, vomiting, stomach pain, loss of appetite; diarrhea.